Comparison of Health Status Among Patients With Type 1 Myocardial Infarction and Type 2 Myocardial Infarction: The CHAMP‐MI Study

Background Improving health status is a fundamental goal after myocardial infarction (MI). Whether health status differs between type 1 and type 2 MI is unknown. Methods In this prospective study, 150 patients hospitalized with type 1 (n=75) and type 2 MI (n=75) were enrolled. Health status was assessed at baseline, 1, and 4 months using the EuroQol 5‐Dimension 5‐Level visual analogue scale, 7‐item Seattle Angina Questionnaire, Patient‐Reported Outcomes Measurement Information System Physical Function, Patient‐Reported Outcomes Measurement Information System Fatigue, FRAIL Scale, and Patient Health Questionnaire‐9. Results A total of 149 baseline, 92 one‐month, and 92 four‐month assessments were analyzed. Patients with type 2 MI were older, were more frequently women, and had more comorbidities. Baseline health status was similar between type 2 and type 1 MI (EuroQol 5‐Dimension 5‐Level visual analog scale, 66.20±22.17 versus 69.36±20.67; P =0.37). At 1 and 4 months, the EuroQol 5‐Dimension 5‐Level visual analog scale was lower for type 2 MI, and adjusted analyses demonstrated less improvement (difference, − 4.8 points; P =0.04). Patients with type 2 MI had lower physical function and greater frailty throughout follow‐up. Baseline fatigue and depression were similar but modestly worse for type 2 MI at follow‐up. Baseline 7‐item Seattle Angina Questionnaire scores were higher for type 2 MI but were similar between groups at follow‐up. Conclusions Although baseline overall health status was similar, patients with type 2 MI experienced smaller improvements in health status and reported a greater burden of frailty and impaired physical function over 4 months. These findings highlight the need to address health status domains beyond angina after type 2 MI.