Key result
Clonidine maintenance links to blood pressure control in ~65% of hypertensive patients.
Why the study?
The long-term effects and clinical response to clonidine treatment in patients with hypertension over several years were not well characterized.
Does clonidine improve blood pressure control in patients with hypertension?
Observational (n=78)
Does clonidine improve blood pressure control in patients with hypertension?
Clonidine provides effective long-term blood pressure control in a majority of hypertensive patients over a 2 to 6 year period.
Answers are grounded in this paper and cite their sources.
Supports potential long-term clonidine use in hypertension; hypothesis-generating and should not change practice without RCTs.
A study of the use of clonidine in the treatment of patients with hypertension, both in hospital and in the community, during a period of 6 years is reported. Seventy-eight patients (42 males and 36 females) with hypertension were studied during this period both in terms of their immediate response to introduction of clonidine and also the effect of maintenance treatment for periods varying between 2 and 6 years. During the period of study, the hypertension was well controlled in 51 (65.4%) patients. In the remaining 27 patients, clonidine treatment was stopped for a variety of reasons but, despite this, the drug provided effective treatment for period of up to 4 years. Nineteen patients died in the course of the study, but in all these cases the blood pressure remained under adequate control. The clinical response to treatment and the incidence of side-effects are described.
No takes yet. Share an insight, caveat, or question.
Lawson et al. (1979) conducted an observational in Hypertension (n=78). Clonidine was evaluated on Well controlled hypertension. Clonidine treatment provided well-controlled blood pressure in 65.4% of 78 hypertensive patients over a follow-up period of 2 to 6 years.
Synapse has enriched 10 related papers. Consider them for comparative context: