Key result
Angiotensin II infusion potentiates osmotic-stimulated plasma ADH increases in preclinical models.
Why the study?
The effect of angiotensin II on the release of ADH in response to an osmotic stimulus was investigated to understand its potentiation role.
Does angiotensin II potentiate the release of ADH in response to an osmotic stimulus in dogs?
Population
Dogs anesthetized with pentobarbital hydrated by 4% glucose iv infusion
Comparison
Infusion of 2.5M NaCl iv with angiotensin II vs 2.5M NaCl iv alone or angiotensin II alone
Design
Preclinical experimental study
Authors
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Should not guide ADH management in patients; leaves open angiotensin II–ADH interactions in human osmoregulation.
Does angiotensin II potentiate the release of ADH in response to an osmotic stimulus in dogs?
Angiotensin II potentiates the release of ADH in response to an osmotic stimulus in a canine model.
Shimizu et al. (1973) studied this question. Angiotensin II vs. Hypertonic saline alone was evaluated on Plasma ADH concentration. Angiotensin II infusion (10 ng/kg per min) significantly potentiated the increase in plasma ADH concentration in response to an osmotic stimulus in anesthetized dogs.
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