Key result
An Epstein-Barr Virus-induced primary cardiac lymphoma on a heart transplant graft progressed rapidly despite multiple treatments and ICD implantation, resulting in sudden death.
Why the study?
Primary cardiac lymphoma on the heart transplant graft is a highly rare complication with poor prognosis and lacks specific and appropriate treatment.
Case Report (n=1)
Primary cardiac lymphoma on a heart transplant graft is a rare complication with a poor prognosis that can present with severe rhythmic complications such as electrical storm.
Answers are grounded in this paper and cite their sources.
Alerts to rapid fatal progression and arrhythmic risk in post-transplant graft lymphoma; leaves open optimal prevention and therapy strategies.
Background: Cancers, and specifically lymphomas, are one of the main causes of morbidity and mortality after heart transplant. We encountered this complication on a 54-year-old male patient, which brought to our attention the lack of a specific and appropriate treatment for a primary cardiac lymphoma on the graft. Objective: This case report highlights the challenging management of primitive heart transplant lymphoma and its treatment. Method: electronic medical record literature reviewed through Pubmed interface of Medline. Result: We report the case of an Epstein-Barr Virus (EBV) induced primary cardiac lymphoma on the graft. The lymphoma spread quickly in spite of the numerous treatments we tried and resulted in rhythmic complication. Endocavitary implantable cardioverter defibrillator was implanted but quickly removed due to local complications. The patient died from a sudden death at home shortly after. Conclusions: Primary cardiac lymphoma on the graft is highly rare with poor prognosis and rhythmic complications. Further studies are needed to assess the benefits of other treatment approaches, such as radiofrequency ablation techniques.
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Charbonneau et al. (2020) conducted a case report in Epstein-Barr Virus (EBV) induced primary cardiac lymphoma on the graft (n=1). Endocavitary implantable cardioverter defibrillator and other treatments was evaluated. An Epstein-Barr Virus-induced primary cardiac lymphoma on a heart transplant graft progressed rapidly despite multiple treatments and ICD implantation, resulting in sudden death.
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