Key result
Male sex is linked to ~93% higher long-term mortality after SAVR for severe aortic stenosis.
Why the study?
There is controversy on whether sex differences affect long-term mortality in patients with severe AS undergoing SAVR.
Does male sex increase long-term mortality in patients with severe aortic stenosis undergoing isolated surgical aortic valve replacement?
Population
917 patients with severe AS undergoing isolated SAVR at a tertiary care center
Comparison
Male sex vs female sex
Design
Retrospective cohort study
Follow-up
Median 5.2 years
Authors
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May inform sex-based risk stratification after SAVR; leaves open prospective validation before clinical adoption.
Cohort (n=917)
No
Does male sex increase long-term mortality in patients with severe aortic stenosis undergoing isolated surgical aortic valve replacement?
Hazard Ratio: 1.93 (95% CI 1.28–2.91)
Absolute Event Rate: 24.7% vs 17.9%
p-value: p=0.002
In patients with severe aortic stenosis undergoing isolated surgical aortic valve replacement, male sex is independently associated with a nearly twofold higher risk of long-term mortality compared to female sex.
Kang et al. (2022) conducted a cohort in Severe aortic stenosis (n=917). Male sex vs. Female sex was evaluated on 10-year mortality (HR 1.93, 95% CI 1.28-2.91, p=0.002). Male sex was associated with significantly higher long-term mortality than female sex after surgical aortic valve replacement for severe aortic stenosis (HR 1.93; 95% CI 1.28-2.91; p=0.002).
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