Key result
Up-slope VF shocks increase defibrillation success ~72% compared to down-slope timing.
Why the study?
It was uncertain whether coordinating transvenous defibrillation shocks with the up/down-slope VF waveform patterns would improve defibrillation success probability.
Does delivering defibrillation shocks on the up-slope of high amplitude VF waveforms improve defibrillation success in a swine model?
Does delivering defibrillation shocks on the up-slope of high amplitude VF waveforms improve defibrillation success in a swine model?
Absolute Event Rate: 67% vs 39%
p-value: p=<0.001
Delivering defibrillation shocks during the up-slope of high amplitude VF signals significantly improves defibrillation success in a preclinical swine model.
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Hypothesis-generating for waveform-timed defibrillation in swine; leaves open translation to human VF resuscitation.
Hsu et al. (1997) studied Ventricular fibrillation (n=8). Defibrillation shocks on the up-slope of high amplitude VF vs. Defibrillation shocks on the down-slope of high amplitude VF was evaluated on Defibrillation success (p=<0.001). Delivering defibrillation shocks during the up-slope of high amplitude ventricular fibrillation signals significantly improved success compared to the down-slope (67% vs 39%; P<0.001).
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