Key result
Lower HDL cholesterol is linked to acute myocardial infarction with no difference in total cholesterol.
Why the study?
The distributions of serum total cholesterol and HDL cholesterol in AMI patients compared to the general population in Kuopio Province were not well characterized.
Case-Control (n=3,263)
HDLC levels are significantly lower in AMI patients compared to the general population, highlighting the importance of HDLC in lipid risk assessment.
As part of the FINMONICA project, serum total cholesterol (TC) and high density lipoprotein cholesterol (HDLC) concentrations were determined in 1216 AMI patients (937 men, 279 women) aged 35-64 years in the province of Kuopio in eastern Finland during the 5-year period 1983-87. The distributions were compared with the corresponding distributions in a representative sample of the general population of the same area (1026 men, 1021 women). The mean serum TC levels did not differ between the AMI patients and the normal population. Only the prevalence of a very high serum TC level (> 8.0 mmol l-1) among women was significantly higher in the AMI group than in the population sample. On the other hand, in both sexes the age-adjusted mean HDLC was significantly lower in the AMI group than in the population sample. Our findings emphasize the importance of HDLC measurement as a part of the assessment of the lipid risk factor profile in patients with AMI.
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Lehto et al. (1993) conducted a case-control in Acute myocardial infarction (n=3,263). Acute myocardial infarction vs. General population was evaluated on Serum total cholesterol and high density lipoprotein cholesterol concentrations. Age-adjusted mean high density lipoprotein cholesterol was significantly lower in patients with acute myocardial infarction than in the general population, whereas mean total cholesterol did not differ.
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