What is the clinical evidence from this study?

Study design: Observational. Population: Normotension (n=193). Intervention: Gbeta3 825T allele vs. Gbeta3 CC genotype. Primary outcome: Response of the renin-angiotensin system and blood pressure to dietary salt restriction.

July 1, 2000Journal of Hypertension

G-protein β3 subunit 825T allele and response to dietary salt in normotensive men

Q: What does this research mean for the field?

The G-protein β3 subunit C825T polymorphism is not associated with salt sensitivity or the response of blood pressure and the renin-angiotensin system to dietary salt restriction in young normotensive men. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Gbeta3 825T allele shows no association with salt sensitivity or renin-angiotensin response in normotensive men.

n=193

Why the study?

The Gbeta3 C825T polymorphism has been implicated in hypertension development, but its role in renin-angiotensin system and blood pressure response to dietary salt restriction is unclear.

Does the Gbeta3 825T allele determine the response of the renin-angiotensin system and blood pressure to dietary salt restriction in young normotensive men?

Population

193 young normotensive men aged 20-30 years

Comparison

Gbeta3 C825T genotypes (CC vs CT vs TT) under low- and high-salt diets

Design

Observational study within the Berlin Salt-Sensitivity Trial

Authors

USUlrike SchorrMax Delbrück Center KBKlaus BlaschkeUniversität Hamburg JBJoachim BeigeUniversity of Southern California

Discussion

Member takes

Implication

Does not support Gbeta3 825T genotyping to guide salt restriction in normotensives; leaves open its role in hypertension or other groups.

Study Design

Type

Observational (n=193)

Structured PICO

Does the Gbeta3 825T allele determine the response of the renin-angiotensin system and blood pressure to dietary salt restriction in young normotensive men?

Population

193 young normotensive men aged 20-30 years old evaluated on low- and high-salt diets to determine if the Gbeta3 825T allele affects salt sensitivity.

Exposure

Gbeta3 C825T polymorphism genotyping (assessing the 825T allele) and exposure to low- (20 mmol/day) and high-salt (220 mmol/day) dietary protocols

Comparator

Comparison between genotypic groups (CC, CT, TT)

Outcome

Response of the renin-angiotensin system and blood pressure to dietary salt restrictionsurrogate

The Gbeta3 C825T polymorphism does not determine the response of the renin-angiotensin system to salt depletion and is not an early genetic marker of salt sensitivity in young normotensive men.

Cite This Study

Schorr et al. (2000) conducted an observational in Normotension (n=193). Gbeta3 825T allele vs. Gbeta3 CC genotype was evaluated on Response of the renin-angiotensin system and blood pressure to dietary salt restriction. The Gbeta3 825T allele was not associated with salt sensitivity or the response of the renin-angiotensin system to dietary salt restriction in young normotensive men (allele frequency 0.32 in both groups).

synapsesocial.com/papers/6ab9db0f013637f052d52826 https://doi.org/10.1097/00004872-200018070-00006

Topics

Hypertension management

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G-protein β3 subunit 825T allele and response to dietary salt in normotensive men

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Topics

G-protein β3 subunit 825T allele and response to dietary salt in normotensive men

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider