Key result
Reperfusion rapidly restores metabolic and cardiodynamic function to control levels after prolonged turtle heart ischemia.
Why the study?
The study aimed to test the hypothesis that turtle hearts tolerate prolonged global ischemia at 20 degrees C and recover completely on reperfusion without ischemia- or reperfusion-related injury.
Population
Isolated turtle hearts (Chrysemys picta bellii)
Comparison
1.5 hours of global ischemia followed by reperfusion vs baseline control levels
Design
Preclinical experimental study using nuclear magnetic resonance spectroscopy
Follow-up
1.5 hours of ischemia followed by reperfusion
Authors
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Turtle heart ischemia tolerance is hypothesis-generating; leaves open mechanisms applicable to mammalian reperfusion injury.
Isolated turtle hearts demonstrate remarkable tolerance to prolonged global ischemia, recovering metabolic and cardiodynamic function completely upon reperfusion without injury.
Wasser et al. (1992) studied global ischemia and reperfusion. 1.5 h of global ischemia vs. control levels was evaluated on metabolic and cardiodynamic recovery on reperfusion. Isolated turtle hearts subjected to 1.5 hours of global ischemia (decreasing ATP to 87.3% of control) rapidly restored metabolic and cardiodynamic parameters to control levels upon reperfusion.
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