Key result
Elevated cTnT affects ~35% of severe pediatric RSV cases but fails to predict clinical outcomes.
Why the study?
The prevalence and nature of myocardial damage in children with severe RSV lung disease were not well characterized.
What is the prevalence and clinical significance of elevated cardiac Troponin T levels in children with severe RSV lung disease?
Population
34 children with severe RSV infection admitted to paediatric intensive care at Royal Liverpool Children's Hospital
Comparison
Children with elevated cTnT levels vs children without elevated cTnT levels
Design
Prospective observational cohort study
Authors
Loading...
cTnT elevation signals myocardial involvement in one-third of severe pediatric RSV cases without worse outcomes; leaves open whether routine screening improves risk stratification.
Cohort (n=34)
No
What is the prevalence and clinical significance of elevated cardiac Troponin T levels in children with severe RSV lung disease?
p-value: p=>0.05
Myocardial involvement, indicated by elevated cTnT, is common in infants with severe RSV lung disease and is associated with hypotension and younger age.
Eisenhut et al. (2004) conducted a cohort in severe respiratory syncytial virus (RSV) lung disease (n=34). Elevated cardiac Troponin T (cTnT) levels vs. Without elevated cTnT levels was evaluated on Severity of disease (duration of ventilation, inotrope requirements, death, echocardiographic abnormalities) (p=>0.05). Elevated cTnT levels occurred in 35% of children with severe RSV and were associated with lower systolic blood pressure (p=0.01), but not with differences in ventilation duration or death.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: