Key result
Novel radioreceptor assay for active ANF correlates strongly with standard RIA at r=~0.93.
Why the study?
A highly sensitive and specific assay for the active circulating form of atrial natriuretic factor in human plasma was needed to improve measurement accuracy.
Population
Human plasma samples and bovine zona-glomerulosa membrane receptors
Comparison
Radioreceptor assay (RRA) vs radioimmunoassay (RIA)
Design
Other (laboratory assay development and validation)
Authors
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May support specific ANF research assays; leaves open clinical adoption without outcome data.
Effect estimate: r = 0.93
A highly sensitive and specific radioreceptor assay was developed for measuring active circulating atrial natriuretic factor in human plasma.
Ong et al. (1988) studied this question. Radioreceptor assay (RRA) for ANF vs. Radioimmunoassay (RIA) was evaluated on Correlation between RRA and RIA for clinical samples (r = 0.93). A highly sensitive radioreceptor assay for the active circulating form of atrial natriuretic factor showed strong correlation (r = 0.93) with radioimmunoassay in clinical samples.
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