Key result
Resection of multiple cardiac calcified amorphous tumors with AVR yields recurrence-free survival past ~2 years.
Why the study?
Cardiac calcified amorphous tumors are rare non-neoplastic cardiac tumors with unknown origin, and multiple simultaneous CATs in different cardiac chambers are uncommon with unclear characteristics and complications.
Case Report (n=1)
No
Early surgical resection is recommended for highly mobile cardiac calcified amorphous tumors due to the high risk of embolization and tissue injury.
Answers are grounded in this paper and cite their sources.
Supports resection consideration for mobile cardiac calcified amorphous tumors; leaves open confirmation of embolization risk and timing in larger series.
BACKGROUND: Cardiac calcified amorphous tumors (CATs) are non-neoplastic cardiac tumors of unknown origin and etiology. Several simultaneous CATs rarely occur in multiple cardiac chambers. Although CATs carry a benign prognosis, they have a risk of complications such as systemic embolism. CASE PRESENTATION: We report the case of a 79-year-old woman with two CATs and aortic regurgitation due to perforations of aortic cusps. She underwent surgical tumor resection with aortic valve replacement. The CATs were macroscopically and histologically different, which may suggest different developmental stages. One CAT was in the left atrium; it was less mobile and had nodular calcifications within dense fibrous tissue. The other CAT was in the left ventricular outflow tract; it was highly mobile, with nodular calcifications surrounded by amorphous fibrin and sanguineous deposits. The highly mobile CAT mechanically damaged the aortic cusps and caused perforations. The patient has survived over 2 years with no recurrence of the cardiac masses on echocardiography. CONCLUSION: The patient underwent surgical resection for two CATs. The tumors occurred in different areas and had different macroscopic and histological characteristics. We recommend early resection for highly mobile CATs because of the high risks of embolization and injuries to the surrounding tissues.
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Sakurai et al. (2023) conducted a case report in Cardiac calcified amorphous tumors (CATs) and aortic regurgitation (n=1). Surgical tumor resection and aortic valve replacement was evaluated on Tumor recurrence and survival. Surgical resection of multiple cardiac calcified amorphous tumors and aortic valve replacement resulted in survival for over 2 years with no recurrence.
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