Key result
Propofol and midazolam showed no significant difference in postoperative memory coefficient (77.35 vs 75.61, p=0.52) or cognitive dysfunction in elderly patients undergoing spinal anesthesia.
Why the study?
Does Propofol reduce cognitive dysfunction compared to Midazolam in elderly patients undergoing spinal anesthesia?
Population
136 elderly patients undergoing spinal anesthesia
Comparison
Propofol (0.2 mg/kg) vs Midazolam (0.02 mg/kg)
Design
RCT, randomly assigned, double-blind
Follow-up
postoperative
Authors
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Propofol confers no cognitive advantage over midazolam; confirms lack of difference in postoperative memory among elderly spinal anesthesia patients.
RCT (n=136)
Double-blind
Randomly assigned
No
Does Propofol reduce cognitive dysfunction compared to Midazolam in elderly patients undergoing spinal anesthesia?
Absolute Event Rate: 77.35% vs 75.61%
p-value: p=0.52
Propofol and midazolam do not differ in their effects on postoperative cognitive dysfunction in elderly patients undergoing spinal anesthesia, though midazolam has a longer onset and recovery time.
Manouchehrian et al. (2023) conducted an RCT in Lower limb surgery under spinal anesthesia (n=136). Propofol vs. Midazolam (0.02 mg/kg) was evaluated on Postoperative memory coefficient (p=0.52). Propofol and midazolam showed no significant difference in postoperative memory coefficient (77.35 vs 75.61, p=0.52) or cognitive dysfunction in elderly patients undergoing spinal anesthesia.
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