Key result
Arginine metabolism drives cardiovascular physiology and disease through NO-dependent and independent pathways.
Why the study?
Knowledge regarding the complex interplay between arginine metabolic pathways at the whole body, tissue, and cellular levels in cardiovascular physiology and pathophysiology is incomplete.
Design
Review article
Authors
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May identify novel arginine-related targets in cardiovascular disease; leaves open therapeutic translation until randomized evidence emerges.
Arginine metabolism plays a complex role in cardiovascular physiology through both NO-dependent and independent pathways, suggesting new avenues for understanding vascular disease.
Sidney M. Morris (2005) conducted a review in Cardiovascular disease. Arginine metabolism was evaluated. Arginine metabolism plays a major role in cardiovascular physiology and pathophysiology via both NO-dependent and -independent processes, though knowledge of the complex interplay remains incomplete.
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