Key result
L-Arginine serves as the essential precursor for nitric oxide synthesis and shows therapeutic potential for improving endothelial function and treating cardiovascular disorders.
Why the study?
Does L-Arginine improve cardiovascular disorders?
Does L-Arginine improve cardiovascular disorders?
L-Arginine is a key substrate for nitric oxide synthesis and represents a potential therapeutic target for managing cardiovascular disorders.
Supports endothelial function hypothesis; leaves open clinical use in cardiovascular disorders pending randomized trials.
The essential amino acid, L-Arginine (L-Arg) has an important role in the cardiovascular system. Literature data show that L-Arg is the only substrate for the production of nitric oxide (NO), from which L-Arg develops its effects on the cardiovascular system. As a free radical, NO is synthesized in all mammal cells by L-Arg with the activity of NO synthase (NOS). In the states of hypertension, diabetes, hypercholesterolemia and vascular inflammation, a disorder occurs in the metabolic pathway of the synthesis of NO from L-Arg which all together bring alterations to blood vessels. Clinical studies show that L-Arg has an effect on thrombocytes, the process of coagulation and the fibrolytic system. All the new data summarized in this review suggest that L-Arg could be one of important therapeutic molecules for improving cardiovascular disorders.
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Sudar-Milovanović et al. (2015) conducted a review in Cardiovascular disorders. L-Arginine was evaluated. L-Arginine serves as the essential precursor for nitric oxide synthesis and shows therapeutic potential for improving endothelial function and treating cardiovascular disorders.
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