Key result
ICIs cause rare but potentially fatal cardiotoxicity, particularly myocarditis requiring prompt high-dose corticosteroids.
Why the study?
Immune checkpoint inhibitors are increasingly used in cancer treatment but are associated with significant cardiovascular toxicity that requires better clinical understanding.
This review summarizes the clinical manifestations, diagnostic approaches, treatment, and surveillance of cardiovascular toxicities associated with immune checkpoint inhibitors.
Heightens vigilance for ICI myocarditis in practice; leaves open optimal protocols pending prospective data.
Recent years have brought major advancements in the use of immune therapy and specifically immune checkpoint inhibitors (ICIs) in cancer patients, with expanding indications for various malignancies resulting in the treatment of a large and increasing number of patients. While this therapy significantly improves outcomes in a variety of hematologic and solid tumors, the use of ICIs is associated with a substantial risk of immune-related adverse events. Cardiovascular toxicity, while not the most common side effect of ICIs, is associated with significant morbidity and mortality. It is therefore crucial for oncologists and cardiologists, as well as internists and emergency room physicians, to have a good understanding of this increasingly common clinical problem. In the present review, we discuss the cardiac aspects of ICI therapy with special emphasis on the clinical manifestations of their cardiovascular toxicity, diagnostic approaches, treatment and suggested surveillance.
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Gilon et al. (2022) conducted a review in Immune checkpoint inhibitor cardiovascular toxicity. Immune checkpoint inhibitors was evaluated. Immune checkpoint inhibitors can cause rare but potentially fatal cardiovascular toxicities, particularly myocarditis, which requires prompt diagnosis and treatment with high-dose corticosteroids.
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