Key result
Immunohistochemistry supports a histiocytic rather than myogenic origin of giant cells in giant cell myocarditis.
Why the study?
The association between giant cell myocarditis and lymphoma was previously unrecorded, and the aetiology of giant cell myocarditis related to immune state changes was hypothesized.
Case Report (n=1)
This case report provides the first recorded association between giant cell myocarditis and non-Hodgkin's lymphoma, suggesting a histiocytic origin for the giant cells.
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Suggests immune dysregulation link in rare co-occurrence; hypothesis-generating and should not yet change practice.
Theaker et al. (1987) conducted a case report in Giant cell myocarditis and non-Hodgkin's lymphoma (n=1). Immunohistochemical investigation was evaluated on Cellular origin of giant cells. Immunohistochemical investigation of a patient with giant cell myocarditis and non-Hodgkin's lymphoma supported a histiocytic rather than myogenic origin for the giant cells.
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