What question did this study set out to answer?

To determine whether the multinucleated giant cells characteristic of giant cell myocarditis arise from muscle cells or immune cells.

February 1, 1985Journal of Clinical PathologyOpen Access

Giant cell myocarditis: evidence for the macrophage origin of the giant cells.

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Population

A case of giant cell myocarditis (n=1)

Design

Case_report

Authors

JTJeffrey TheakerSouthampton General Hospital KGKevin C. GatterUniversity of Copenhagen AHA HeryetSouthmead Hospital

Discussion

Member takes

Implication

Immunohistological analysis of a giant cell myocarditis case suggests that giant cells originate from macrophages rather than muscle cells.

Key Points

To determine whether the multinucleated giant cells characteristic of giant cell myocarditis arise from muscle cells or immune cells.
Conducted an immunohistological evaluation of cardiac tissue in a single patient case (N=1).
Stained tissue sections using monoclonal antibodies directed against muscle- and macrophage-specific antigens.
Immunohistological staining strongly demonstrates that the abnormal giant cells derive from macrophages.
Reactivity patterns confirm giant cells do not originate from muscle cells.

Structured PICO

Population

A case of giant cell myocarditis (n=1)

Intervention

Immunohistological analysis using monoclonal antibodies against muscle and macrophage antigens

Outcome

Origin of giant cells

Immunohistological analysis of a giant cell myocarditis case suggests that giant cells originate from macrophages rather than muscle cells.

Cite This Study

Theaker et al. (1985) studied this question.

synapsesocial.com/papers/6a910e02647f40dea9c1af74 https://doi.org/10.1136/jcp.38.2.160

Topics

Myocarditis

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Implication

Immunohistological analysis of a giant cell myocarditis case suggests that giant cells originate from macrophages rather than muscle cells.

Giant cell myocarditis: evidence for the macrophage origin of the giant cells.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Giant cell myocarditis: evidence for the macrophage origin of the giant cells.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider