Key result
Multinucleated giant cells in experimental autoimmune myocarditis are formed by the aggregation and fusion of inflammatory macrophages and subsequently undergo apoptosis.
Authors
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Does not alter myocarditis management; leaves open whether macrophage fusion drives human giant cell disease.
Suzuki et al. (1995) studied Experimental autoimmune myocarditis. Immunization with cardiac myosin fraction was evaluated on Morphological and immunohistochemical characteristics of multinucleated giant cells and their apoptosis. Multinucleated giant cells in experimental autoimmune myocarditis are formed by the aggregation and fusion of inflammatory macrophages and subsequently undergo apoptosis.
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