Key result
Amiodarone use linked to elevated liver enzymes and CT-detected hepatic hyperdensity mimicking hemochromatosis.
Why the study?
Amiodarone treatment can cause increased liver density on unenhanced CT and elevated liver enzymes, but clinical recognition and monitoring strategies are unclear.
Case Report (n=1)
Answers are grounded in this paper and cite their sources.
Clinicians should consider amiodarone effects in liver CT interpretation; leaves open prevalence and diagnostic utility in larger cohorts.
This is a case report in which a 60-year-old man who suffered from ventricular tachycardia with dilated cardiomyopathy was prescribed amiodarone. After taking amiodarone, liver enzymes were increased and computed tomographic (CT) scanning of the abdomen showed a significant increase in the density of the liver without contrast medium. He was suspected as hemochromatosis and liver biopsy was performed. An abnormal high density of liver tissue may be observed in an unenhanced CT in patients treated with amiodarone and we suggest that periodic monitoring of liver function and/or liver biopsy is warranted before an irreversible stage is reached.
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Kojima et al. (2009) conducted a case report in Ventricular tachycardia with dilated cardiomyopathy (n=1). Amiodarone was evaluated on Increased liver enzymes and increased density of the liver on unenhanced CT. Amiodarone use was associated with increased liver enzymes and abnormally high liver density on unenhanced CT, mimicking hemochromatosis.
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