IMPULSE: the impact of gender on the presentation and management of aortic stenosis across Europe
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Key result
Female sex is associated with ~20% higher likelihood of undergoing TAVI over SAVR in severe AS.
- P<0.001
- n=2,171
Why the study?
There is increasing awareness of gender-related differences in patients with severe aortic stenosis and their outcomes after SAVR and TAVI.
Population
2171 patients with severe aortic stenosis enrolled between March 2015 and April 2017
Comparison
Female vs male patients with severe aortic stenosis
Design
Observational registry analysis (IMPULSE)
Authors
Discussion
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Implication
Gender differences shape TAVI/SAVR assignment in severe AS; leaves open whether sex-specific strategies improve outcomes.
Study Design
Type
Observational (n=2,171)
Multicenter
Yes
PICO
P
Population
2,171 patients aged 18 years or older with severe aortic stenosis enrolled in a European registry and followed for 3 months to assess gender differences in presentation and management.
E
Exposure / Comparator
Female gender vs Male gender
O
Primary Outcome
Scheduled to undergo transcatheter aortic valve implantation (TAVI), p=<0.001
Main Result
Absolute Event Rate: 49.3% vs 41%
p-value: p=<0.001
Limitations
- Lack of adjustment for confounding variables when comparing genders
- Findings may not be generalisable to regions outside of Europe
Cite This Study
Steeds et al. (2021) conducted an observational in Severe aortic stenosis (n=2,171). Female gender vs. Male gender was evaluated on Scheduled to undergo transcatheter aortic valve implantation (TAVI) (p=<0.001). Among patients with severe aortic stenosis, women were more frequently scheduled to undergo TAVI (49.3% vs 41.0%) and less frequently for SAVR (20.3% vs 27.5%) compared to men.
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