Key result
Combination antihypertensive therapy is linked to fewer adverse drug reactions than monotherapy in diabetic hypertension.
Why the study?
Adverse drug reactions associated with antihypertensive drugs in diabetic patients were evaluated due to their impact on patients and healthcare systems.
Observational (n=740)
Open-label
No
Absolute Event Rate: 42.3% vs 57.6%
May suggest fewer ADRs with combination therapy in diabetic hypertension; hypothesis-generating and should not change practice without RCTs.
Adverse drug reactions (ADRs) present a serious public health problem that can affect patients, caregivers, pharmaceutical companies, and the health care system as a whole. The objective of the present study was to evaluate Adverse Drug Reactions associated with antihypertensive drugs in diabetic patients. The present study was an open, non-comparative, observational study done to monitor ADRs associated with antihypertensive medications in diabetic patients in a multispeciality hospital. A total of 347 adverse drug reactions were observed in 740 diabetic hypertensive patients during 2008-2010. A high percentage of ADRs occurred in elderly and female patients. Of the 347 ADRs, 185 (53.3%) were mild, 122 (35.1%) were moderate and 40 (11.5%) were identified to be severe. Combination therapy was associated with significantly less occurrence of ADRs, with a total of 147 (42.3%) as compared to monotherapy (n=200, 57.6%). Among the various antihypertensive drugs used in diabetic patients, diuretics were associated with higher number of ADRs (37.1%), followed by ACE inhibitors (34.2%), beta blockers (18.1%) and calcium channel blockers (10.3%).
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Beulah et al. (2012) conducted an observational in Hypertension and Diabetes (n=740). Combination antihypertensive therapy vs. Antihypertensive monotherapy was evaluated on Adverse drug reactions (ADRs). Combination antihypertensive therapy was associated with fewer adverse drug reactions (42.3% of total ADRs) compared to monotherapy (57.6%) in diabetic hypertensive patients.
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