Key result
Dietary squalene prevents isoprenaline-induced myocardial injury in rats via antioxidant and antilipidemic effects.
Why the study?
The cardioprotective effect of squalene against isoprenaline-induced myocardial infarction in rats was investigated to understand its potential antilipidemic and antioxidant properties.
Does squalene supplementation prevent biomarker elevation and oxidative stress in an isoprenaline-induced myocardial infarction rat model?
Does squalene supplementation prevent biomarker elevation and oxidative stress in an isoprenaline-induced myocardial infarction rat model?
p-value: p=<0.001
Squalene supplementation demonstrates cardioprotective, antilipidemic, and antioxidant effects in a rat model of isoprenaline-induced myocardial infarction.
Supports squalene cardioprotection in rat MI model; hypothesis-generating, leaves open human translation and should not change practice.
This study was designed to examine the cardioprotective effect of squalene against isoprenaline-induced myocardial infarction in male albino rats. Levels of diagnostic markers [troponin T, homocysteine], lipoproteins [apolipoprotein Al, apolipoprotein B, lipoprotein (a)] (in plasma), total cholesterol, lipid peroxides (in plasma and heart tissue), and endogenous non-enzymatic antioxidants [vitamin C and vitamin E] (in heart tissue) were determined. Supplementation of squalene at 2% level along with feed for 45 days significantly prevented the isoprenaline-induced elevation in the diagnostic markers in plasma of experimental group of rats. It exerted an antilipidemic action against isoprenaline-induced hypercholesterolemia by maintaining the levels of cholesterol and lipoprotein components at near normalcy. Squalene supplementation exhibited an antioxidant effect against isoprenaline-induced myocardial infarction by blocking the induction of lipid peroxidation. A tendency to prevent the isoprenaline induced reduction in the non-enzymatic antioxidants such as vitamin E and C was also observed. The results of the present study indicate that the cardioprotective effect of squalene might be ascribable to its antilipidemic, antioxidant and membrane stabilizing properties.
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T.V. et al. (2025) studied Isoprenaline-induced myocardial infarction (n=24). Squalene vs. Standard diet with added coconut oil at 2% level was evaluated on Levels of diagnostic markers (troponin T, homocysteine), lipoproteins, total cholesterol, lipid peroxides, and endogenous non-enzymatic antioxidants (p=<0.001). Supplementation of squalene at 2% for 45 days significantly prevented isoprenaline-induced elevation in diagnostic markers (p<0.001), exhibiting antilipidemic and antioxidant cardioprotective effects in rats.
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