Key result
CAD genetic study discrepancies stem largely from inconsistent phenotyping of cases and controls.
Why the study?
There is inconsistency in genetic studies of coronary artery disease due to difficulties in defining cases and controls despite advances in genotyping technology.
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Phenotypic standardization is essential before interpreting CAD genetic associations; leaves open whether refined definitions will yield replicable loci.
Luo et al. (2006) conducted a review in Coronary artery disease and acute myocardial infarction. Phenotypic characterization in genetic studies was evaluated. Inconsistencies in genetic studies of coronary artery disease are largely due to variability and challenges in the phenotypic characterization of cases and controls.
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