Key result
Newer antihypertensive drug classes reduce adverse effects and improve adherence over 30-year evolution.
Why the study?
Many antihypertensive agents have been introduced over the past 30 years with varying mechanisms and side effect profiles, motivating a review of their evolution.
May enhance compliance via better tolerability; leaves open which new classes improve hard outcomes.
During the past 30 years many antihypertensive agents, acting at differing levels on the mechanisms controlling arterial blood pressure, have been introduced. 2. Whereas the usefulness of early drugs was limited by side effects, the discovery of successive classes of agents has resulted in the gradual introduction of drugs causing fewer adverse effects with consequent improvements in patient compliance. 3. The recent appearance of angiotensin II antagonists and potassium channel openers, together with increased knowledge of the roles played by atrial natriuretic factor and endothelial cell-derived autacoids in control of vascular tone, hold prospects for still further improvements in therapy.
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Ronald D. Robson (1992) conducted a review in Hypertension. Antihypertensive therapy was evaluated. The evolution of antihypertensive therapy over 30 years has led to newer classes of agents with fewer adverse effects, improving patient compliance and offering prospects for further advancements.
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