Key result
Hemodialysis linked to ~9-fold higher odds of ECG abnormalities versus non-CKD controls.
Why the study?
Chronic kidney disease-related cardiovascular impairments may affect myocardial electrical activation, but electrocardiographic abnormalities in dialysis-naïve versus hemodialysis patients were not well described.
Does chronic hemodialysis increase the prevalence of electrocardiographic abnormalities in patients with chronic kidney disease compared to dialysis-naïve and non-CKD patients?
Cross-Sectional (n=150)
No
Does chronic hemodialysis increase the prevalence of electrocardiographic abnormalities in patients with chronic kidney disease compared to dialysis-naïve and non-CKD patients?
Hemodialysis patients have a significantly higher prevalence of electrocardiographic abnormalities, particularly left ventricular hypertrophy, QT prolongation, and left atrial hypertrophy, compared to dialysis-naïve CKD and non-CKD patients.
Answers are grounded in this paper and cite their sources.
Supports heightened ECG vigilance in hemodialysis; hypothesis-generating for prospective outcome studies in CKD.
RÉSUMÉIntroduction. Les atteintes du système cardiovasculaire liées à la maladie rénale chronique (MRC) peuvent avoir des répercussions sur l’activation électrique du myocarde. Notre but était de décrire les anomalies électrocardiographiques chez les patients souffrant de MRC comparativement aux patients MRC hémodialysés chroniques. Matériel et méthodes. Il s’agissait d’une étude transversale et analytique conduite à l’hôpital général de Douala de février à juin 2021. Nous avons réalisé un électrocardiogramme à 3 groupes de patients appariés selon l’âge et le sexe dont 50 sans MRC (Non MRC), 50 avec MRC non hémodialysés (MRC-ND) et 50 avec MRC hémodialysés (HD). Une valeur p < 0,05 était considérée significative. Résultats. Sur 150 patients inclus, 87 (58%) étaient de sexe masculin et l’âge moyen était similaire dans les 3 groupes (53,06 (11,64) ans chez les HD, 53,85 (11,53) ans chez les MRC ND et 53.84 (11,74) ans chez les non MRC). Les anomalies électrocardiographiques étaient significativement retrouvées chez les HD (86%) par rapport aux MRC ND (56%) et non MRC (24%) (OR=9,2 ; IC : 3,77-22,51, P < 0,0001). Ces anomalies étaient l’HVG (66%, OR = 8.84, IC : 4.06 – 19.22, p < 0,0001), l’intervalle QT allongé (28%, OR=5,16, IC :1,93 –13,84 et p = 0,001) et l’HAG (26%, OR=6.67, IC :2.27 – 20.03, p = 0,0006). Conclusion. Les anomalies ECG étaient fréquentes chez les patients HD, notamment l’HVG, l’intervalle QT allongé et l’HAG. Ces résultats incitent à améliorer les interventions spécifiques sur les causes de l’HVG chez l’hémodialysé telles l’hypertension artérielle et l’anémie. ABSTRACTIntroduction. Chronic kidney disease (CKD)-related impairment of the cardiovascular system may affect myocardial electrical activation. The aim of this study was to describe electrocardiographic abnormalities in patients with CKD compared to stable chronic haemodialysis patients. Material and methods. This was a cross-sectional and analytical study at the Douala General Hospital from February to June 2021. We performed an electrocardiogram in 3 groups of patients matched according to age and sex, including 50 without CKD (Non-CKD), 50 with CKD but dialysis naïve (CKD-ND) and 50 with CKD on hemodialysis (HD). A p-value < 0.05 was considered significant. Result. In total, of 150 patients included, 87 (58%) were male and the mean age was similar in the 3 groups (53.06 (11.64) years in HD patients, 53.85 (11.53) years in ND CKD patients and 53.84 (11.74) years in non-CKD patients). Electrocardiographic abnormalities were significantly found (OR=9,2 ; CI : 3,77-22,51 and P < 0,0001) in HD patients (86%) than ND CKD patients (56%) and non-CKD patients (24%) . These abnormalities found in HD patients were LVH (66%, OR = 8.84, CI : 4.06 – 19.22, p < 0,0001),QT prolongation (28%, OR=5,16, CI :1,93 –13,84 and p = 0,001) and left atrial hypertrophy (LAH) (26%, OR=6.67, IC :2.27 – 20.03 and p = 0,0006). Conclusion. Electrocardiographic abnormalities are significantly more frequent in HD patients, particularly LVH, QT interval prolongation and LAH. These results suggest an improvement of specific interventions on the causes of LVH and LAH in hemodialysis patients such as arterial hypertension and anemia.
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Mouliom et al. (2022) conducted a cross-sectional in Chronic kidney disease (n=150). Hemodialysis vs. Dialysis-naïve CKD and non-CKD patients was evaluated on Electrocardiographic abnormalities (OR 9.2, 95% CI 3.77-22.51, p=<0.0001). Hemodialysis patients had a higher prevalence of electrocardiographic abnormalities compared to dialysis-naïve chronic kidney disease patients and non-CKD controls.
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