Key result
Primary pericardial synovial sarcoma poses critical diagnostic challenges due to highly non-specific cardiac presentations.
Why the study?
Pericardial synovial sarcoma is a rare primary malignant cardiac tumor with challenging diagnosis due to its non-specific presentation.
Case Report (n=1)
This case report highlights the presentation and diagnostic challenges of pericardial synovial sarcoma, a rare primary malignant tumor of the heart.
May prompt inclusion of synovial sarcoma in differentials for atypical pericardial masses in young adults; leaves open standardized diagnostic approaches for rare cardiac tumors.
Pericardial synovial sarcoma [PSS] is a sporadic rare primary malignant tumour of the heart. It belongs to a category of synovial sarcoma [SS] which accounts for approximately 5-10% of all soft tissue sarcomas and 4th most common sarcoma. Mostly occur in people aged 20 to 40 years [1]. SS usually occurs in the extremities near joints, though it can rarely appear in other sites such as thoracic cavity [2]. Patients usually present with a deep-seated mass that has been present for several years. Most synovial sarcoma show a characteristic chromosomal translocation t(x;18) (p11;q11.2) producing SS18-SSX1-SSX2 or SSX4 fusion genes that encode chimeric transcription factors [3]. Histologically PSS may be monophasic, characterized by uniform spindle cells, or biphasic, containing both spindle and epithelial components. The diagnosis of PSS can be challenging due to its non-specific presentation. Today we will discuss one such case.
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Guru et al. (2026) conducted a case report in Pericardial synovial sarcoma (n=1). Pericardial synovial sarcoma is a rare primary malignant tumor of the heart that presents diagnostic challenges due to its non-specific presentation.
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