Key result
A theoretical model derived an explicit formula for the dependence of the critical shear rate on von Willebrand factor molecule size, introducing the Platelet Activation Risk Index (PARI).
Why the study?
The value of the critical shear rate above which von Willebrand factor activates platelets remains controversial despite extensive experimental data, and its dependence on VWF multimer size has not been elucidated.
Answers are grounded in this paper and cite their sources.
PARI may refine shear-dependent thrombosis models; leaves open prospective validation before any clinical use.
Platelet activation in blood flow under high, overcritical shear rates is initiated by Von Willebrand factor. Despite the large amount of experimental data that have been obtained, the value of the critical shear rate, above which von Willebrand factor starts to activate platelets, is still controversial. Here, we recommend a theoretical approach to elucidate how the critical blood shear rate is dependent on von Willebrand factor size. We derived a diagram of platelet activation according to the shear rate and von Willebrand factor multimer size. We succeeded in deriving an explicit formula for the dependence of the critical shear rate on von Willebrand factor molecule size. The platelet activation risk index was introduced. This index is dependent on the flow conditions, number of monomers in von Willebrand factor, and platelet sensitivity. Probable medical applications of the platelet activation risk index as a universal prognostic index are discussed.
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Zlobina et al. (2016) studied Thrombosis. Shear rate and von Willebrand factor multimer size was evaluated on Critical shear rate for platelet activation. A theoretical model derived an explicit formula for the dependence of the critical shear rate on von Willebrand factor molecule size, introducing the Platelet Activation Risk Index (PARI).
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