May 23, 2014Journal of Cardiovascular Electrophysiology
The Impact of Nonsustained Ventricular Tachycardia on Reverse Remodeling, Heart Failure, and Treated Ventricular Tachyarrhythmias in MADIT‐CRT
Key result
NSVT in CRT-D patients is linked to ~189% higher heart failure risk in nonischemic cardiomyopathy.
- HR 2.89
- 95% CI 1.49-5.61
- P=0.002
Why the study?
The predictive value of nonsustained ventricular tachycardia (NSVT) on clinical events in MADIT-CRT patients treated with CRT-defibrillator was unclear.
Comparison
Patients with NSVT vs patients without NSVT
Design
Cohort study analyzing 24-hour Holter recordings
Authors
Discussion
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Implication
May inform NSVT-based risk stratification in nonischemic CRT-D patients; leaves open need for prospective outcome trials.
Study Design
Type
Cohort
Multicenter
Yes
PICO
P
Population
Patients with ischemic or nonischemic cardiomyopathy treated with a CRT-defibrillator in the MADIT-CRT trial.
E
Exposure / Comparator
Nonsustained ventricular tachycardia (NSVT) vs Absence of NSVT
O
Primary Outcome
Heart failure events in nonischemic cardiomyopathy — HR 2.89 (1.49-5.61), p=0.002
Main Result
Hazard Ratio: 2.89 (95% CI 1.49–5.61)
p-value: p=0.002
Cite This Study
Mittal et al. (2014) conducted a cohort in Cardiomyopathy treated with CRT-defibrillator. Nonsustained ventricular tachycardia (NSVT) vs. Absence of NSVT was evaluated on Heart failure events in nonischemic cardiomyopathy (HR 2.89, 95% CI 1.49-5.61, p=0.002). The presence of nonsustained ventricular tachycardia in CRT-D patients was associated with an increased risk of heart failure in nonischemic cardiomyopathy (HR 2.89; 95% CI 1.49-5.61; P=0.002).