Key result
Complete RV failure markedly elevates central venous pressure and increases volume expansion requirements.
Why the study?
The hemodynamic consequences and volume requirements of complete right ventricular failure with extracorporeal left ventricular support were not fully characterized.
RV failure raises venous pressure despite LV replacement; leaves open optimal RV support strategies in human LVAD use.
By replacing the left ventricle of a dog with an extracorporeal pump, complete failure of the right ventricle (e.g., fibrillation) caused marked elevation of central venous pressure, the Degrees of elevation being a linear function of left ventricular output. In addition, expansion of the intravascular volume was required in order to maintain circulation by the left ventricle alone. Edema formation was accentuated by the hypervolemia and venous hypertension.
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Rose et al. (1956) studied Complete right ventricular failure. Extracorporeal left ventricle pump and induced right ventricular failure was evaluated on Central venous pressure, intravascular volume requirement, and edema formation. Complete right ventricular failure in dogs maintained with an extracorporeal left ventricle caused marked elevation of central venous pressure and required expansion of intravascular volume.
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