Key result
Clinical trial data do not support the American Heart Association 2007 guidelines recommending systolic blood pressure reduction to less than 130 mm Hg or 120 mm Hg in high-risk patients.
Why the study?
Clinical trial data do not support the AHA 2007 guideline recommendations for systolic blood pressure targets in patients with hypertension at high risk for coronary events or with left ventricular systolic dysfunction.
BP targets <130 mm Hg in high-risk hypertension warrant caution in LV systolic dysfunction; leaves open optimal thresholds pending higher-level evidence.
The American Heart Association (AHA) 2007 guidelines recommend treating patients with hypertension at high risk for coronary events such as those with coronary artery disease, diabetes mellitus, chronic kidney disease, or a 10-year Framingham risk score of 10% or higher to have their systolic blood pressure reduced to less than 130 mm Hg [1]. These guidelines also recommend that patients with hypertension and left ventricular systolic dysfunction have their systolic blood pressure reduced to less than 120 mm Hg [1]. However, clinical trial data do not support these guidelines for treatment of patients with hypertension [2-17].
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Wilbert S. Aronow (2013) conducted an editorial in Hypertension. Systolic blood pressure reduction to <130 mm Hg or <120 mm Hg was evaluated. Clinical trial data do not support the American Heart Association 2007 guidelines recommending systolic blood pressure reduction to less than 130 mm Hg or 120 mm Hg in high-risk patients.
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