Key result
Ectopic ANP secretion from small cell lung cancer confirms paraneoplastic etiology of SIADH.
Why the study?
Ectopic production of atrial natriuretic peptide in small cell lung cancer with SIADH had not been previously demonstrated.
Population
One autopsy case with small cell lung cancer and SIADH
Design
Case report
Authors
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May expand paraneoplastic SIADH mechanisms in SCLC; leaves open prevalence and clinical relevance pending larger studies.
Case Report (n=1)
Shimizu et al. (1991) conducted a case report in Small cell lung cancer and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) (n=1). Ectopic atrial natriuretic peptide (ANP) production was evaluated on Presence of high levels of ANP and AVP in tumor tissue and plasma. Ectopic atrial natriuretic peptide (ANP) production and its secretion into blood leading to SIADH was confirmed in an autopsy case of small cell lung cancer.
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