Key result
Overweight and obesity linked to better prognosis than leaner weight in established CVD.
Why the study?
Despite obesity increasing CVD risk factors and total CVD, overweight and obese patients with established CVD often have better prognosis than leaner patients, a phenomenon known as the obesity paradox.
Answers are grounded in this paper and cite their sources.
Obesity paradox observed in established CVD; leaves open optimal weight targets for secondary prevention.
The effects of overweight and obesity on chronic diseases, particularly on cardiovascular disease (CVD), and its impact on increasing CVD risk factors and total CVD are reviewed. However despite the adverse effects of obesity on CVD risk factors and CVD, obesity has a surprising association with prognosis in patients with established diseases, often showing an "obesity paradox," [corrected] where overweight (body mass index (BMI), 25 to 29.9 kg·m(-2)) and obese patients (BMI, ≥30 kg·m(-2)) with established CVD frequently have a better prognosis than that of their leaner counterparts (BMI, <25 kg·m(-2)) with the same diseases. Fitness-versus-fatness debate is summarized also, including the critical role that fitness plays to alter the relationship between adiposity and subsequent prognosis.
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Lavie et al. (2014) conducted a review in Cardiovascular disease. Overweight and obesity vs. Leaner counterparts (BMI <25 kg/m2) was evaluated on Prognosis in patients with established diseases. Overweight and obese (BMI ≥30 kg/m2) patients with established CVD frequently have a better prognosis than leaner counterparts (BMI <25 kg/m2).
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