High-throughput label-free opioid receptor binding assays using an automated desorption electrospray ionization mass spectrometry platform

This is the authors' abstract. We don't add key points for this paper.

The current opioid epidemic has incentivized the discovery of new non-addictive analgesics, a process that requires the screening of opioid receptor binding, traditionally performed using radiometric assays. Here we describe a label-free alternative based on high-throughput (1 Hz) ambient mass spectrometry for screening the receptor binding of new opioid analogues.