November 30, 2015European Heart Journal - Cardiovascular Imaging
OCT imaging of aorto-coronary vein graft pathology modified by external stenting: 1-year post-surgery
Key result
External stenting reduces saphenous vein graft lumen area ~10% vs. unstented grafts at 1 year.
- P=0.005
- n=24
Why the study?
The impact of a novel external stent on saphenous vein graft pathology after CABG surgery was not fully characterized using OCT imaging.
Comparison
SVGs with external stenting vs SVGs without external stenting
Design
Sub-study of a randomized controlled trial using OCT imaging
Follow-up
1 year post-surgery
Authors
Discussion
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Implication
External stenting produces more uniform SVG lumens without thrombus at 1 year; leaves open whether these OCT changes reduce clinical graft failure.
Study Design
Type
RCT (n=24)
PICO
P
Population
24 patients (mean age 65 years) enrolled in the VEST trial who underwent CABG surgery, evaluated at 1 year post-surgery with OCT imaging.
I
Intervention / Comparator
External stenting of saphenous vein grafts vs Unstented saphenous vein grafts
O
Primary Outcome
Mean cross-sectional area, p=0.005
Main Result
Absolute Event Rate: 7.6% vs 8.4%
p-value: p=0.005
Cite This Study
Webb et al. (2015) conducted an RCT in Coronary artery disease requiring CABG (n=24). External stenting of saphenous vein grafts vs. Unstented saphenous vein grafts was evaluated on Mean cross-sectional area (p=0.005). External stenting of saphenous vein grafts resulted in a smaller mean cross-sectional area (7.6 vs 8.4 mm; P=0.005) and a more homogeneous lumen compared to unstented grafts at 1 year.