Encapsulation and Characterization of Fucoidan-Curcumin Nano Micelle for Anti-inflammatory Effects

Curcumin is a potential bioactive compound used for many healthcare applications.Due to its hydrophobic nature therapeutic index is reduced many folds.Encapsulation of curcumin in a hydrophilic polymeric micelle enhances its bioavailability in biological systems.Fucoidan is a functional polysaccharide isolated from brown sea-weeds possess various health beneficial applications.In the present work, curcumin was encapsulated in fucoidan polymeric nano micelle (FCN).The optimal contact time for the encapsulation of curcumin was found to be 24 hours, average size of nano micelle formed 121 + 0.1 nm with 67% curcumin encapsulation efficiency.Zeta potential was maximum of -47.4 which shows electro-kinetic potential in colloidal dispersions of Fucoidan Curcumin Nano Micelle (FCN).Physical Characterization of FCN was performed using FTIR spectroscopy and conjugation of fucoidan and curcumin was confirmed based on peak shift at wave number 2215 cm -1 ; 1639 cm-1; 1517 cm -1 and 1265 cm -1 .Analysis of SEM, and TEM images were performed to know the nature of encapsulation of curcumin in polymeric micelle.Results obtained from in vitro assays such as antioxidant, anti-hemolytic and anti-inflammatory showed potential bioactive properties of FCNs.