Key result
Cardiomyopathy with arterial thromboembolism is linked to paradoxical hypocoagulability with ~3-fold longer reaction times.
Why the study?
Acquired heart disease leading to congestive heart failure in cats was characterized by various cardiac lesions across different age groups.
Case-Control (n=30)
No
Absolute Event Rate: 12% vs 4%
p-value: p=<0.001
May prompt reevaluation of antithrombotic assumptions in feline cardiomyopathy with thromboembolism; leaves open mechanisms and optimal management pending prospective data.
SUMMARY Acquired heart disease leading to congestive heart failure was diagnosed in 112 of 1,554 cats consecutively necropsied. The principal cardiac lesions were nonsuppurative endocarditis and myocarditis in cats 1.3 ± 0.8 years old; focal endocardial and myocardial fibrosis, fusion of chordae tendineae, fibrosis of the mitral valve, left ventricular hypertrophy, and left atrial dilatation and hypertrophy in cats 7.3 ± 4.0 years old; and diffuse myocardial and endocardial fibrosis with dilatation of the left and right ventricles in cats 10.3 ± 1.4 years old. Other lesions were passive congestion of lungs and liver; renal infarction; red thromboemboli localized in the aorta, carotid arteries, femoral arteries, iliac arteries, renal arteries, left and right atria, and pulmonary and hepatic vessels; pericardial and pleural effusion; and ascites.
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Si-Kwang Liu (1970) conducted a case-control in Cardiomyopathy and Arterial Thromboembolism (n=30). Arterial thromboembolism in cardiomyopathy vs. Cardiomyopathy without arterial thromboembolism and healthy cats was evaluated on Reaction time (R) on whole blood thromboelastography (WB-TEG) in minutes (p=<0.001). Cats with cardiomyopathy and arterial thromboembolism demonstrated a paradoxical systemic hypocoagulable state, characterized by significantly prolonged reaction time and decreased peak thrombin generation compared to healthy controls.
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