Key result
DOCA-induced hypertension links to smooth muscle hyperplasia and increased medial area in peripheral renal arteries.
Why the study?
The increase in peripheral resistance in hypertension has been attributed to adaptive hypertrophy or contracture of the arterial wall, but detailed morphometric data in hypertensive rats were needed.
Hyperplasia may contribute to vascular remodeling in hypertension; hypothesis-generating for mechanisms in human disease.
The increase in peripheral resistance of the vascular bed in hypertension has been attributed to adaptive hypertrophy of the media or a so-called contracture of the arterial wall due to altered reactivity of smooth muscle cells. We have measured medial cross-sectional area, numbers of smooth muscle cell nuclei and the relative proportions of scleroproteins present in the media in hypertensive rats. The results show that hyperplasia of smooth muscle cells and an increase in medial area occur in hypertension, a change most marked in the peripheral branches of the renal artery.
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Berry et al. (1982) studied Hypertension. DOCA-induced hypertension was evaluated on Medial cross-sectional area, numbers of smooth muscle cell nuclei and relative proportions of scleroproteins. DOCA-induced hypertension in rats was associated with hyperplasia of smooth muscle cells and an increase in medial area, most marked in the peripheral branches of the renal artery.
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