Why the study?
Do antihypertensive treatments (reserpine or captopril) or correction of renal ischaemia prevent or reverse vascular smooth muscle cell hyperplasia in rats with renal hypertension?
Population
Rat model of renal hypertension
Comparison
Reserpine, captopril, or correction of renal… vs Untreated renal hypertension
Design
Preclinical
Authors
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Supports non-BP mechanisms of vascular hyperplasia in this rat model; leaves open relevance to human renal hypertension.
Do antihypertensive treatments (reserpine or captopril) or correction of renal ischaemia prevent or reverse vascular smooth muscle cell hyperplasia in rats with renal hypertension?
In a rat model of renal hypertension, blood pressure reduction with captopril does not prevent vascular smooth muscle hyperplasia, suggesting blood pressure is not the sole determinant of vascular wall remodeling.
Rorive et al. (1980) studied this question.
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