Key result
Impaired renal function linked to ~6-fold higher odds of severe CAD.
Why the study?
Cardiovascular disease is the leading cause of morbidity and mortality in renal impaired patients, and the association between renal impairment and coronary artery disease severity in chronic stable angina patients needed evaluation.
Observational (n=110)
Answers are grounded in this paper and cite their sources.
Renal impairment may link to greater CAD severity in stable angina; leaves open whether intensified management improves outcomes in CKD.
Background: Cardiovascular disease is the leading cause of morbidity and mortality in renal impaired patients. Many of the patients of chronic kidney disease die of cardiovascular disease before requiring dialysis. Cardiovascular disease in renal impaired patient is potentially preventable and treatable. The aim of this study was to evaluate the association between renal impairment and coronary artery disease severity in chronic stable angina patients. Methods: 110 patients with chronic stable angina who got admitted for coronary angiography were included in the study. They were divided into impaired renal function group (with estimated glomerular filtration rate [eGFR] <90 ml/min/1.73m2) and normal renal function group (eGFR e 90 ml/min/1.73m2) on the basis of eGFR. The severity of the CAD was assessed by angiographic Vessel score and Gensini score. Results: Mean Gensini score was significantly high in impaired renal function group (42.30±24.9 vs 25.65±17.9, p <0.05). There was significant negative correlation between eGFR and vessel score (r=-0.30, p <0.05) and between eGFR and Gensini score (r =-0.65, P <0.05). In multivariate logistic regression analysis, after adjustment of factors eGFR remain independent predictors of severe CAD (P=0.002, OR -5.73). Conclusion: Impaired renal function, assessed by eGFR is associated with angiographic severe coronary artery disease in chronic stable angina patients and this association is independent of conventional cardiovascular risk factors. DOI: http://dx.doi.org/10.3329/cardio.v7i1.20796 Cardiovasc. j. 2014; 7(1): 17-23
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Saha et al. (2014) conducted an observational in Chronic stable angina (n=110). Impaired renal function (eGFR <90 ml/min/1.73m2) vs. Normal renal function (eGFR ≥90 ml/min/1.73m2) was evaluated on CAD severity assessed by mean Gensini score (p=<0.05). Impaired renal function was associated with higher mean Gensini scores compared to normal renal function and independently predicted severe CAD.
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