Key result
Post-COVID syndrome in ACS is linked to ~67% higher risk of hypokinesis and akinesis.
Why the study?
The impact of post-COVID syndrome on echocardiographic changes in patients with acute coronary syndrome was not well characterized.
Does post-COVID syndrome worsen echocardiographic parameters and increase the risk of structural cardiac complications in patients presenting with acute coronary syndrome?
Cohort (n=239)
No
Does post-COVID syndrome worsen echocardiographic parameters and increase the risk of structural cardiac complications in patients presenting with acute coronary syndrome?
Relative Risk: 1.673 (95% CI 1.275–2.196)
Absolute Event Rate: 54.6% vs 30.2%
p-value: p=<0.001
Patients with acute coronary syndrome and post-COVID syndrome exhibit more severe echocardiographic abnormalities, including increased pulmonary artery pressure and a higher risk of structural complications like left ventricular aneurysms and thrombi, compared to ACS patients without post-COVID syndrome.
Objective: to evaluate echocardiographic changes in patients with acute coronary syndrome (ACS) combined with post-COVID syndrome. Material and methods. The study included 118 patients, including 61 men and 57 women with ACS and a post-COVID syndrome. All patients underwent echocardiography on the first day, in addition to coronary angiography and general clinical examination methods. The comparison group consisted of 121 patients with ACS without post-COVID syndrome. Results. In the ACS and post-COVID syndrome group, statistically significant increases in blood pressure (relative risk — RR 2.327, 95% confidence interval — Cl 1.582-2.699), tachycardia (RR 2.067, 95% Cl 1.415-3.730), dyspnea (RR 2.022, 95% Cl 1.495-2.736), weakness (RR 4.077, 95% Cl 2.946-5.643), and insomnia (RR 1.893, 95% Cl 1.519-2.358); p<0,001, were recorded. In the group of patients with ACS and post-COVID syndrome, there was a statistically significant increase in the mean pulmonary artery pressure, dilation of the pulmonary artery diameter, and regurgitation on the mitral valve (p<0,001). The risk of developing left ventricular apex thrombosis (RR 1.785, 95% Cl 1.304-2.444), left ventricular aneurysms (RR 1.736, 95% Cl 1.23-2.443), hypokinesis and akinesis (RR 1.673, 95% Cl 1.275-2.196); p<0,05, was observed more often. Conclusion. Patients who have had ACS combined with post-COVID syndrome show more severe echocardiographic changes compared to patients without post-COVID syndrome.
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Kozik et al. (2025) conducted a cohort in Acute coronary syndrome with post-COVID syndrome (n=239). Post-COVID syndrome vs. Acute coronary syndrome without post-COVID syndrome was evaluated on Hypokinesis and akinesis (development of myocardial infarction) (RR 1.673, 95% CI 1.275-2.196, p=<0.001). Acute coronary syndrome patients with post-COVID syndrome had a significantly higher risk of hypokinesis and akinesis (RR 1.673) compared to those without post-COVID syndrome.
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