Key result
Borderline hypertensive offspring of hypertensive patients show altered leukocyte sodium-potassium pump activity.
Why the study?
Cellular sodium-potassium pump activity in mononuclear leukocytes from borderline hypertensive offspring of hypertensive patients was investigated to understand pump function alterations.
Observational
Answers are grounded in this paper and cite their sources.
Does not support changes in hypertension management; hypothesis-generating for leukocyte Na-K pump alterations in familial risk.
Uptake of 86Rubidium of mononuclear leukocytes (MNL) was used as a measure of cellular sodium-potassium pump activity. 86Rb-uptake was determined with the pump stimulated mainly from inside the cells by sodium as well as with a combined stimulation from inside by sodium and from outside by Rb. In the first case there was an increased pump activity in MNL from borderline hypertensive offspring of hypertensive patients (BHO), and this may be related to an increased number of pump sites observed previously (10). Estimation of maximal pump activity (Vmax) of MNL suggested that Vmax of each pump site in MNL from BHO may be decreased compared to control value of MNL from healthy normotensive subjects.
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Johansen et al. (1985) conducted an observational in Borderline hypertension / Family history of essential hypertension. Borderline hypertensive offspring of hypertensive patients vs. Healthy normotensive subjects was evaluated on 86Rubidium uptake of mononuclear leukocytes (cellular sodium-potassium pump activity). Mononuclear leukocytes from borderline hypertensive offspring of hypertensive patients demonstrated increased overall sodium-potassium pump activity but potentially decreased maximal pump activity per site.
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