Outcome, efficacy and safety of endovascular thrombectomy in ischaemic stroke according to time to reperfusion: data from a multicentre registry

Figure 1.. Day 90 functional outcome at 3 months according to time to reperfusion. Distribution of mRS scores at 3 months, according to time to reperfusion strata. Analysis was done using multivariable binary logistic regression analysis adjusting for prespecified confounders outlined in the methods section for TTR per hour increase. The thick green line proposed by Goyal and colleagues indicates a highly significant beneficial treatment effect with higher rate of the primary outcome mRS 0–2 (aOR 0.933, 95% CI 0.887–0.981, p = 0.007). The thin green line indicates a significant beneficial treatment effect with higher rate of mRS 0–1 (aOR 0.929, 95% CI 0.877–0.985, p = 0.013) and mRS 0–3 (aOR 0.955, 95% CI 0.911–1.000, p = 0.049). The thin red line indicates a beneficial, but non-significant, treatment effect for mortality (aOR 0.988, 95% CI 0.933–1.046, p = 0.680). mRS, modified Rankin scale.

Figure 2.. Probability of good functional outcome (mRS 0–2) with margins plot, including 95% confidence intervals. For this analysis, time to reperfusion was used as a continuous variable and multivariable binary logistic regression analysis was performed, adjusting for prespecified confounders outlined in the methods section. Per hour delay of reperfusion there was a 1.5% decreased probability of good functional outcome. mRS, modified Rankin scale.

Figure 3.. Adjusted odds ratio of successful reperfusion (mTICI⩾2b/3) for outcome parameters. Adjusted odds ratio of successful reperfusion (mTICI⩾2b/3) for outcome parameters stratified for patients with time to reperfusion from symptom onset (TTR) of less or more than 7 h. mRS, modified Rankin scale; sICH, symptomatic intracranial haemorrhage; TTR, time to reperfusion from symptom onset.