Key result
Intensive medical therapy restores LVEF to ~60% in severe DKA-induced cardiomyopathy.
Why the study?
Takotsubo cardiomyopathy in the setting of diabetic ketoacidosis is a rare phenomenon attributed to severe acidosis with limited reported cases.
Case Report (n=1)
Suggests reversibility of DKA cardiomyopathy with intensive support; hypothesis-generating and requires prospective validation.
Stress-induced or Takotsubo cardiomyopathy (TCM) is a phenomenon that typically occurs in postmenopausal women in the setting of acute emotional or medical stressors. It typically causes reversible akinesis of the heart apex with opposite hyperdynamic basal segments. An electrocardiogram (ECG) would show ischemic ST elevation in anterior leads in >90% of cases with elevated troponin, yet coronary angiography rules out occlusive disease. Takotsubo cardiomyopathy in the setting of diabetic ketoacidosis (DKA) is a rare phenomenon that has been attributed to severe acidosis. Here, we report the case of a 37-year-old male with severe DKA that was complicated by stress cardiomyopathy and progressed to cardiogenic shock.
No takes yet. Share an insight, caveat, or question.
Abbas et al. (2022) conducted a case report in Diabetic Ketoacidosis-Induced Cardiomyopathy (n=1). Intensive medical management (vasopressors and hemodialysis) was evaluated on Clinical and echocardiographic recovery. Intensive medical management including vasopressors and hemodialysis led to the full recovery of left ventricular ejection fraction from less than 30% to 60% in a 37-year-old man with DKA-induced cardiomyopathy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: