Leishmania genomic adaptation: more than just a 36-body problem

Genome instability has been identified as a major driver of adaptation in fast-growing, eukaryotic cells, including fungi, protists, or cancer. How these cells cope with the toxic effects caused by such copy number variations remains to be elucidated. In recent years, the protist parasites Leishmania spp. have emerged as interesting model pathogens to assess this open question and to study the role of its intrinsic genome instability in fitness gain in culture, experimental infection, and in the field. Here we summarize recent results on Leishmania genomic adaptation and propose thought-provoking evolutionary concepts new to the Leishmania field that need to be considered when mapping genotype-to-phenotype relationships in molecular and epidemiological studies.