Why the study?
The benefit of cranial radiation boost added to total body irradiation prior to allo-HCT in ALL patients without prior CNS involvement was not established.
Should an implantable cardioverter-defibrillator generator be replaced at the time of battery depletion in patients who have never received an electrical discharge?
Should an implantable cardioverter-defibrillator generator be replaced at the time of battery depletion in patients who have never received an electrical discharge?
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Provides a clinical decision-making framework for elective ICD generator replacement in patients without prior device discharges, emphasizing LVEF recovery (>45%), myocardial fibrosis on MRI, life expectancy, procedural complication risks, and shared decision-making.
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Cadena-Sillas et al. (2026) conducted a review in Implantable cardioverter-defibrillator (ICD) battery depletion without prior electrical discharge. Elective ICD generator replacement vs. Avoidance of ICD generator replacement or device de-escalation to CRT-P/pacemaker was evaluated.
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