Key result
Adenosine potentiation measures duration of action across cardiac glycosides in preclinical model.
Why the study?
A method suitable for determining the duration of action of cardiac glycosides and aglycones with short duration of action was needed, as previous methods were more suitable for longer durations.
Answers are grounded in this paper and cite their sources.
New guinea-pig assay enables duration testing of short-acting glycosides; leaves open clinical translation.
A method is described for determining the duration of action of cardiac glycosides and aglycones in the guinea-pig. It is based on their property of potentiating the cardiac response to adenosine. The method is particularly suitable for those drugs with a short duration of action, whereas previous methods are more suitable for those drugs with longer durations of action. The duration of action of one-fifth of the lethal dose has been found for: digoxigenin, lanatoside C, ouabain, digitoxigenin-3-one, digitoxin, 3-acetyldigitoxigenin, digoxin, digitoxigenin, lanatoside A; these drugs are arranged in order of increasing duration of action. The possible relationship between the elimination of these drugs and their duration of action can provide an estimate of their rates of elimination.
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Anne Stafford (1959) studied this question. Cardiac glycosides and aglycones was evaluated on Duration of action. A method based on potentiating the cardiac response to adenosine established the duration of action for various cardiac glycosides and aglycones in the guinea-pig.
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