Nitric Oxide–producing Enzymes and Serum Cortisol Levels in Patients With Q-Wave Myocardial Infarction During Treatment Dynamics

Q: What are the key findings of this study?

Temgicoluril added to standard therapy in patients with Q-wave myocardial infarction preserved total nitric oxide production and maintained optimal adaptive serum cortisol concentrations compared to standard therapy alone.

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Acute myocardial infarction (n=80). Intervention: Temgicoluril vs. Standard therapy. Primary outcome: Serum cortisol concentration (nmol/L) (p=<0.05).

Q: What does this research mean for the field?

The COVID-19 pandemic initiated a shift toward later-stage detection of EC in the Sumy region, which was followed by a sharp but transient disruption in detection during martial law in 2022 before returning to pre-war levels by 2023–2024. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate the effect of adding temgicoluril to standard therapy on nitric oxide synthase isoform activities, nitrite and peroxynitrite levels, and serum cortisol in patients with Q-wave myocardial infarction.

O. O. Honchar

doi:10.29254/2077-4214-2026-3-182-253-258

January 1, 2026Bulletin of Problems Biology and MedicineOpen Access

Nitric Oxide–producing Enzymes and Serum Cortisol Levels in Patients With Q-Wave Myocardial Infarction During Treatment Dynamics

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Key result

Temgicoluril boosts serum cortisol ~1.9-fold vs. standard therapy alone in Q-wave MI.

P<0.05
n=80

Why the study?

Does the addition of temgicoluril to standard therapy modulate nitric oxide production and cortisol levels in patients with Q-wave myocardial infarction?

Key Points

To evaluate the effect of adding temgicoluril to standard therapy on nitric oxide synthase isoform activities, nitrite and peroxynitrite levels, and serum cortisol in patients with Q-wave myocardial infarction.
Assayed blood activities of inducible (iNOS), endothelial (eNOS), and neuronal (nNOS) nitric oxide synthases alongside levels of nitrites, peroxynitrites, and cortisol during standard therapy with or without temgicoluril.
Standard treatment protocols reduced excessive nitric oxide production across all investigated nitric oxide synthase isoforms.
Standard therapy decreased the formation of toxic reactive nitrogen species and lowered blood cortisol levels.
Adjunctive temgicoluril preserved overall nitric oxide production through reduced inhibition of inducible nitric oxide synthase and sustained higher circulating cortisol levels.

Study Design

Type

RCT (n=80)

Multicenter

No

Structured PICO

Does the addition of temgicoluril to standard therapy modulate nitric oxide production and cortisol levels in patients with Q-wave myocardial infarction?

P

Population

80 adults with acute myocardial infarction (Q-wave and non-Q-wave) treated with percutaneous coronary intervention, followed for 1 month.

I

Intervention

Temgicoluril 500 mg oral 3 times daily for 1 month, added to standard post-MI therapy and rehabilitation.

C

Comparator

Standard post-MI therapy (dual antiplatelet therapy, beta-blockers, ACE inhibitors, statins, and proton pump inhibitors) and rehabilitation without temgicoluril.

O

Outcome

Activity of NO-producing enzymes (iNOS, eNOS, nNOS), concentration of nitrites, peroxynitrites, and serum cortisol after 1 month of treatment.surrogate

Main Result

Absolute Event Rate: 126.16% vs 66.37%

p-value: p=<0.05

Adding temgicoluril to standard post-MI therapy preserves total nitric oxide production by modulating iNOS activity and maintains adaptive cortisol levels, suggesting potential cytoprotective benefits in Q-wave MI.

Limitations

Lack of long-term clinical observations to evaluate long-term cardiovascular outcomes
Detailed mechanisms of temgicoluril's effect on the ischemic myocardium require further study

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Implication

May preserve nitric oxide and cortisol in Q-wave MI; hypothesis-generating and should not change practice.

Abstract

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Discussion

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Cite This Study

O. O. Honchar (2026) conducted an RCT in Acute myocardial infarction (n=80). Temgicoluril vs. Standard therapy was evaluated on Serum cortisol concentration (nmol/L) (p=<0.05). Temgicoluril added to standard therapy in patients with Q-wave myocardial infarction preserved total nitric oxide production and maintained optimal adaptive serum cortisol concentrations compared to standard therapy alone.

synapsesocial.com/papers/6ac6e3c182aa59ee98b3fe6f https://doi.org/10.29254/2077-4214-2026-3-182-253-258

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Nitric Oxide–producing Enzymes and Serum Cortisol Levels in Patients With Q-Wave Myocardial Infarction During Treatment Dynamics

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Nitric Oxide–producing Enzymes and Serum Cortisol Levels in Patients With Q-Wave Myocardial Infarction During Treatment Dynamics

Key Points

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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