Key result
Paravalvular leak closure more effectively reduces hemolysis in mechanical vs. biological valves by modifying micro-jets.
Why the study?
The therapeutic effect of paravalvular leak closure on hemolysis after valve surgery and its relationship to regurgitation volume and micro-jets is unclear.
May support selective paravalvular leak closure for mechanical-valve hemolysis; leaves open non-volume mechanisms and prospective validation.
Paravalvular leak closure may have a therapeutic effect on the extent of hemolysis that some patients experience after valve surgery. Reduction of hemolysis is most likely in a patient with a mechanical valve and is not necessarily correlated with the volume of regurgitative flow or its subsequent reduction. Hemolysis associated with biological valves are less likely to respond to perivalvular leak closure suggesting that mechanisms other than net volume of regurgitation or micro-jets are present and should be considered.
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Ian C. Gilchrist (2019) conducted an editorial in Hemolysis due to perivalvular leaks after valve surgery. Paravalvular leak closure was evaluated. Paravalvular leak closure is more likely to reduce hemolysis in patients with mechanical valves compared to biological valves, driven by modification of micro-jets rather than regurgitant volume.
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