Key result
Bariatric surgery markedly reduces circulating MCP-4, MIP-1β, and eotaxin-3 levels at 10 months.
Why the study?
The involvement of adipokines MCP-4, MIP-1β, and eotaxin-3 in severe obesity, related comorbidities, and their changes after bariatric surgery were not well characterized.
Cohort (n=100)
Answers are grounded in this paper and cite their sources.
May mediate CV risk reduction after bariatric surgery; hypothesis-generating and requires prospective validation.
The aim of the study was to investigate the involvement of the adipokines eotaxin-3, MIP-1β, and MCP-4 in obesity and related comorbidities and the modification of their circulating levels after bariatric surgery. Eighty severely obese subjects and 20 normal-weight controls were included in the study. Circulating levels of MCP-4, MIP-1β, and eotaxin-3, and the main clinical, biochemical, and instrumental parameters for the evaluation of cardiovascular and metabolic profile were determined in controls and in obese subjects at baseline and 10 months after surgery. Within the obese group at baseline, eotaxin-3 levels were higher in males than females and in smokers than non-smokers and showed a positive correlation with LDL-cholesterol, apolipoprotein B, and leptin. MIP-1β showed a positive correlation with age and leptin and a negative correlation with adiponectin and was an independent predictor of increased carotid artery intima-media thickness. MCP-4 levels were higher in obese subjects than controls and showed a positive correlation with body mass index, eotaxin-3, and MIP-1β. Bariatric surgery induced a marked decrease in all the 3 adipokines. MCP-4 is a novel biomarker of severe obesity and could have an indirect role in favoring sub-clinical atherosclerosis in obese patients by influencing the circulating levels of eotaxin-3 and MIP-1β, which are directly related to the main atherosclerosis markers and risk factors. The reduction of circulating levels of MCP-4, eotaxin-3, and MIP-1β could be one of the mechanisms by which bariatric surgery contributes to the reduction of cardiovascular risk in these patients.
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Gentili et al. (2016) conducted a cohort in Severe obesity (n=100). Bariatric surgery vs. Baseline (pre-surgery) and normal-weight controls was evaluated on Circulating levels of MCP-4, MIP-1β, and eotaxin-3. Bariatric surgery induced a marked decrease in the circulating levels of MCP-4, MIP-1β, and eotaxin-3 at 10 months post-operation.
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